China (Mainland)
1197-18-8 Tranexamic acid exporter In China CAS NO.1197-18-8
- FOB Price: USD: 220.00-225.00 /Kilogram Get Latest Price
- Min.Order: 1 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T,Other
- Available Specifications:
Medicine Grade(1-10)Kilogram Medicine Grade(10-500)Kilogram
- Product Details
Keywords
- 1197-18-8 Tranexamic acid
- 1197-18-8 Tranexamic acid exporter
- 1197-18-8 Tranexamic acid In China
Quick Details
- ProName: 1197-18-8 Tranexamic acid exporter In ...
- CasNo: 1197-18-8
- Molecular Formula: C8H15NO2
- Appearance: White Powder
- Application: Tranexamic Acid ,a mechanism of work t...
- DeliveryTime: 15 days
- PackAge: AS YOUR NEED
- Port: any port of China
- ProductionCapacity: 100 Kilogram/Day
- Purity: 99%min
- Storage: Cool and Dry
- Transportation: by sea or air
- LimitNum: 1 Kilogram
- Related Substances: Not detected
- Residue on Ignition: Complies
- Heavy Metal: Not detected
- Valid Period: 2 Years
- Molecular Weight: 157.210
- EINECS No: 214-818-2
Superiority
Tranexamic acid is an inhibitor of fibrinolysis that inhibits the interaction of plasmin with fibrin (IC50 = 3.1 µM in isolated human plasma). It decreases α-naphthylisothiocyanate (ANIT)-induced increases in the expression of the profibrogenic genes Timp1 and Col1a1, but not Itgb6, Tgfβ1, or Tgfβ2, and reduces protein levels of cytokeratin 19 (CK19) and type I collagen in the liver after 28 days in a mouse model of chronic bile duct injury
Fibrinolysis, the cleavage of fibrin by plasmin, is a normal step in the dissolution of fibrin clots after wound repair. Tranexamic acid is an inhibitor of fibrinolysis that blocks the interaction of plasmin with fibrin (IC50 = 3.1 μM). It is a lysine mimetic that binds the lysine binding site in plasmin. Antifibrinolytic agents have value when fibrinolytic activity is abnormally high or when coagulation is impaired.
Details
Tranexamic Acid is a synthetic derivative of the amino acid lysine with antifibrinolytic activity. With strong affinity for the five lysine-binding sites of plasminogen, tranexamic acid competitively inhibits the activation of plasminogen to plasmin, resulting in inhibition of fibrinolysis; at higher concentrations, this agent noncompetitively inhibits plasmin. This agent has a longer half-life, is approximately ten times more potent, and is less toxic than aminocaproic acid, which possesses similar mechanisms of action.
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Product name
Tranexamic acid, plasminogen activation inhibitor
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Description
Antifibrinolytic and plasminogen activation inhibitor
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Biological description
Antifibrinolytic and plasminogen activation inhibitor. Blocks lysine-binding sites of plasmin and elastase-derived plasminogen fragments (IC50 = 5 mM).
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Purity
> 98%
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CAS Number
1197-18-8
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Chemical structure