China (Mainland)
59277-89-3 Acyclovir price CAS NO.59277-89-3
- FOB Price: USD: 58.00-60.00 /Metric Ton Get Latest Price
- Min.Order: 500 Metric Ton
- Payment Terms: L/C,D/A,D/P,T/T,
- Available Specifications:
usp(500-1000)Metric Tonusp(1000-2000)Metric Ton
- Product Details
Keywords
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Quick Details
- ProName: 59277-89-3 Acyclovir price
- CasNo: 59277-89-3
- Molecular Formula: C8H11N5O3
- Appearance: White to light yellow crystal powder
- Application: A synthetic acyclic purine nucleoside ...
- DeliveryTime: 15 days
- PackAge: 25kg/drum
- Port: any port of China
- ProductionCapacity: 1000 Kilogram/Day
- Purity: 99%
- Storage: Avoid contact with water
- Transportation: by sea or air
- LimitNum: 500 Metric Ton
- Related Substances: Not detected
- Residue on Ignition: Complies
- Heavy Metal: Not detected
- Valid Period: 2 Years
- Molecular Weight: 225.21
- Test Method: HPLC
- Sulphated Ash: 0.01%
- Heavy metals: <10ppm
Superiority
Acyclovir is an antiviral compound that can be used to induce apoptosis in cells transfected with herpes simplex virus thymidine kinase (HSV-TK). The compound may exert inhibitory effects through the alterations of the cell cycle in leukemia cells lines, such as p185BCR-ABL expressing OM9:22 cells, by synchronizing the G0/G1 phase. Formation of acycloguanosine triphosphate occurs through the phosphorylation of HSV-TK and can inhibit the viral DNA polymerase. Acyclovir also has the ability to inhibit the proliferation of the fibroblast cells, NIH 3T3, transformed with v-abl or bcr-abl.
Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC50 of 0.85 μM), HSV-2 (IC50 of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia.
Details
Acyclovir is an antiviral agent with activity against herpesvirus types 1 and 2 and varicella zoster virus. Acyclovir is converted by a herpesvirus enzyme into acyclovir triphosphate) that inhibits the synthesis of deoxyribonucleic acid (DNA) molecules in the virally infected cells, thereby inhibiting viral replication.
| Catalogue Number | A192400 |
| Chemical Name | Acyclovir |
| Synonyms | 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one; 9-[(2-Hydroxyethoxy)methyl]guanine; Acycloguanosine; Acicloftal; Cargosil; Gerpevir; Herpevir; Zovirax; Zyclir; Valaciclovir EP Impurity B; |
| Impurity | Valaciclovir EP Impurity B |
| CAS Number | 59277-89-3 |
| Molecular Formula | C?H??N?O? |
| Appearance | White to Off-White Solid |
| Melting Point | >240°C (dec.) |
| Molecular Weight | 225.20 |
| Storage | -20°C Freezer |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Category | Standards; Pharmaceutical/API Drug Impurities/Metabolites; Anti-virals/Anti-retrovirals; |
| Applications | Acyclovir (Valaciclovir EP Impurity B) is an orally active acyclic nucleoside with inhibitory activity towards several herpes viruses. Antiviral. |