62893-20-3 Cefoperazone sodium price CAS NO.62893-20-3

Cefoperazone Sodium is an antimicrobial agent useful for prevention of postoperative infection. Cefoperazone sodium is also an inhibitor of inactivation of α(1)-antitrypsin. As a cephalosporin antibiotic, Cefoperazone sodium has been studied in upper and lower respiratory tract infection treatments, as well as gynecological and skin infection treatments. Cefoperazone sodium is also being investigated for its use in the the treatment of bacteremia.

Cefoperazone sodium is a third-generation, antipseudomonalcephalosporin that resembles piperacillinchemically and microbiologically. It is active against manystrains of P. aeruginosa, indole-positive Proteus spp.,Enterobacter spp., and S. marcescens that are resistant tocefamandole. It is less active than cephalothin againstGram-positive bacteria and less active than cefamandoleagainst most of the Enterobacteriaceae. Like piperacillin,cefoperazone is hydrolyzed by many of the β-lactamasesthat hydrolyze penicillins. Unlike piperacillin, however, itis resistant to some (but not all) of the β-lactamases thathydrolyze cephalosporins.Cefoperazone is excreted primarily in the bile. Hepaticdysfunction can affect its clearance from the body.