33818-15-4 Citicoline sodium in stock CAS NO.33818-15-4

Citicoline sodium salt is a nontoxic intermediate in the biological synthesis of phosphotidylcholine from choline. Studies indicate that Citicoline sodium salt can increase dopamine receptor densities. In addition, Citicoline sodium salt induces the increases Adrenocorticotropic hormone (ACTH) levels in a Corticotropin-releasing hormone (CRH) independent manner. Other hormones of the hypothalamic–pituitary–adrenal axis are also increased such as LH, FSH, GH and TSH. Studies conducted on brain cells show that Citicoline sodium salt can reverse the toxic effects caused by hypoxia, ischemia, and trauma. It is suggested that these neuroprotective properties of Citicoline sodium salt may involve reinforcement of intracellular glutathione antioxidative system, attenuation of phospholipase A, activation and prevention of phospholipid degradation, and prevention of glutamate neurotoxicity. We also offer Citicoline as Cytidine 5'-diphosphocholine, Sodium Salt (CDP-choline), sc-278862.

Naturally occurring nucleotide; intermediate in the major pathway of lecitin biosynthesis. Neuroprotective. It is used in the treatment of ischemic stroke and head trauma. Neuroprotective product. Citicholine exhibits protective effects in cerebral ischemia, traumatic brain injury, and memory disorders. Recently showed efficacy against dementia when given with AchEIs (Acetylcholinesterase inhibitor) (1). Depicts Neuroprotective, acnticonvulsant activity and sedative effect at a dose of 150mg/kg in rats. (2). Showed protection against aluminum induced cognitive impairment in rats reducing elevated glutamate level, oxidative stress and NO overproduction in the hippocampus.

Naturally occurring nucleotide; intermediate in the major pathway of lecitin biosynthesis. Neuroprotective. It is used in the treatment of ischemic stroke and head trauma.