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Home > Products >  51481-61-9 cimetidine High Purity

51481-61-9 cimetidine High Purity CAS NO.58-14-0

  • FOB Price: USD: 63.00-72.00 /Kilogram Get Latest Price
  • Min.Order: 1 Kilogram
  • Payment Terms: L/C,D/A,D/P,T/T,Other
  • Available Specifications:

    Medicine Grade(1-100)Kilogram Medicine Grade(100-1000)Kilogram

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Quick Details

  • ProName: 51481-61-9 cimetidine High Purity
  • CasNo: 58-14-0
  • Molecular Formula: C12H13ClN4
  • Appearance: White Powder
  • Application: Used for pesticides and reagents for a...
  • DeliveryTime: 15 days
  • PackAge: AS YOUR NEED
  • Port: any port of China
  • ProductionCapacity: 100 Kilogram/Day
  • Purity: 99%min
  • Storage: Cool and Dry
  • Transportation: by sea or air
  • LimitNum: 1 Kilogram
  • Related Substances: Not detected
  • Residue on Ignition: Complies
  • Heavy Metal: Not detected
  • Valid Period: 2 Years
  • Molecular Weight: 248.711
  • EINECS No: 200-364-2

Superiority

Cimetidine is a histamine H2 receptor antagonist (Ki = 0.6 μM). It also acts as an inverse agonist, inhibiting basal cAMP production in CHO cells expressing recombinant H2 receptors (IC50 = 1.2 μM). Cimetidine inhibits histamine-induced acid secretion from isolated bullfrog gastric mucosa (IC50 = 16 μM).In vivo, it inhibits histamine-induced gastric acid secretion in gastric fistulae and Heidenhain pouches in dogs (ED50 = 1.88 μmol/kg, p.o.). Cimetidine (20 mg/kg per day) also reduces tumor growth and neovascularization in a CMT93 colon cancer mouse syngeneic model.
 
Cimetidine is an immunomodulator and a histamine congener. Cimetidine competitively inhibits histamine binding to histamine H2 receptors, and suppresses the growth of several tumors, including gastrointestinal cancer. This compound is an anti-angiogenic agent. Cimetidine is an activator of Nischarin.

Details

Cimetidine is a medical drug that inhibits acid production by specific cells in the human stomach and can be dispensed orally or intravenously. Cimetidine is an effective remedy for heartburn that is resultant of a sour stomach or acid indigestion. The drug also reliefs heart burn that is associated with the consumption of certain beverages and foods.


Cimetidine is used in the treatment of ulcers and the prevention of certain conditions that may influence the stomach to produce excess amounts of acid. The drug is also used for the treatment of gastrointestinal reflux disease (GERD), a condition when stomach acid accumulates and oozes into the esophagus resulting in heartburn.
Some of the conditions associated with overproduction of acid by the stomach may include systemic mastocytosis, Zollinger-Ellison syndrome, and multiple endocrine adenomas. Cimetidine is an effective remedy for these conditions as it decreases the amount of acid produced by the stomach.

 A histamine H2-receptor antagonist that inhibits stomach acid production. It is largely used in the treatment of heartburn and peptic ulcers.

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