64485-93-4 Cefotaxime Sodium Factory CAS NO.64485-93-4

Cefotaxime is a cephalosporin antibiotic with potent in vitro activity against streptococcal species, including S. aureus (IC₅₀ = 2 µg/ml) and penicillin-resistant S. pneumoniae. It is also effective against a wide range of other β-lactamase-producing bacterial species (MIC₉₀s = 0.01 - 130 µg/ml). Cefotaxime acts by interfering with bacterial cell wall synthesis and has also been shown to be a competitive inhibitor of β-lactamase.

Cefotaxime sodium salt is a third generation Cephalosporin β-lactamase resistant antibiotic with efficacy in prohibition of gram-positive and gram-negative bacterial cell wall synthesis. Cefotaxime sodium salt has demonstrated greater activity than other available first- and second-generation cephalosporins against Enterobacteriaceae. Cefotaxime sodium salt is more active than older cephalosporins against Pseudomonas aeruginosa and Acinetobacter spp., but most strains are still considered resistant. Cefotaxime sodium salt is also active against some gram-negative bacilli that are resistant to aminoglycosides, including amikacin (sc-278692). The activity of Cefotaxime sodium salt is comparable with other cephalosporins against gram-positive cocci, except staphylococci and enterococci, which are resistant. In combination with penicillins or aminoglycosides, Cefotaxime sodium salt may be synergistic against selected gram-negative bacilli.

• Product name

  Cefotaxime sodium, cephalosporin antibiotic

• Description

  Third-generation cephalosporin antibiotic

• Biological description

  Third-generation cephalosporin antibiotic. Binds to the penicillin-binding proteins (PBPs) therefore inhibiting the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. Active in vitro and in vivo.

• Purity

  > 96%

• CAS Number

  64485-93-4

• Chemical structure